The goal of QGRS-H Predictor is to map and analyze phylogenetically conserved putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the mRNAs, ncRNAs and other nucleotide sequences -e.g. Promoter and Telomeric and gene flank regions. The putative G-quadruplexes are identified using the following motif:
Where x = # guanine tetrads in the G-quadruplex and y1, y2, y3 = length of gaps
QGRS-H Predictor web tool generates information on composition and distribution of putative homologous G-quadruplexes in semi-globally aligned nucleotide sequences based on published algorithms.
Enter 2 sequences in the input area to the left to run an analysis. You may enter RefSeq mRNA Accession or GI#'s and the application
will automatically retrieve the sequence data from NCBI. You may also enter either of the sequences in their raw or FASTA format if Accession or GI#'s are not applicable. Alternatively, you may select one of the homologous pairs in the sample section below.
The program is limited to mRNA sequences less than 10,000 bases in length.
Quick-start tutorialProject background
Menendez, C., Frees, S., and Bagga, P. (2012) QGRS-H Predictor: A Web Server
for Predicting Homologous Quadruplex forming G-Rich Sequence Motifs in
Nucleotide Sequences. Nucleic Acids Res. doi: 10.1093/nar/gks42240: W96-W103